Hydration and hydroamination of 1-alkynes with ruthenium catalysts

Rsc_cc_c1cc13486h 1..3

In recent years, considerable effort has been devoted to develop methodologies which reduce multi-step transformations into one-step tandem processes. In this regard, the use of multifunctional catalysts, which promote sequential reaction steps without additional requirement of additives and/or co-catalysts, provides an effective way while taking care of two most basic challenges faced by a syn...

Hydroamination of Terminal Alkynes by Amines Catalyzed by Copper Heteropoly Salts: A Simple Approach Towards Imine Synthesis

The hydroamination reaction offers a very attractive route for the synthesis of alkylated amines and their derivatives with no byproduct formation. Heterogeneous intermolecular hydroamination reactions of alkynes with aromatic amines using different inexpensive copper salts of hetropolyacid catalysts were investigated. Among heteropoly salts, copper salts of silicotungstic acid showed highest a...

Grafting of water-soluble phosphines to dendrimers and their use in catalysis: positive dendritic effects in aqueous media.

Generations 1 to 3 of dendrimers ended by water-soluble phosphines are synthesized and their ruthenium complexes are used as catalysts in aqueous media; a slightly positive dendritic effect on the regioselectivity is observed for hydration of alkynes and a large positive dendritic effect is observed in the biphasic (water/heptane) catalysed isomerisation of allylic alcohols to ketones where the...

Synthesis and application of gold-carbon hybrids as catalysts for the hydroamination of alkynes

Is the tungsten(IV) complex (NEt4)2[WO(mnt)2] a functional analogue of acetylene hydratase?

The tungsten(IV) complex (Et4N)2[W(O)(mnt)2] (1; mnt = maleonitriledithiolate) was proposed (Sarkar et al., J. Am. Chem. Soc.1997, 119, 4315) to be a functional analogue of the active center of the enzyme acetylene hydratase from Pelobacter acetylenicus, which hydrates acetylene (ethyne; 2) to acetaldehyde (ethanal; 3). In the absence of a satisfactory mechanistic proposal for the hydration rea...